This week sees the final tranche of matches in the Champions League last-16 round.
United scored a 0-0 draw in the first leg in Spain, which means a score-draw for Sevilla at Old Trafford would advance them into the quarterfinals.
For the record, Sevilla have already registered a score draw in England in the Champions League as they drew 2-2 with Liverpool at Anfield in the group stage.
Man United without Paul Pogba
The big absentee for Man United against Sevilla is set to be Paul Pogba.
While Jose Mourinho did his best on Monday to suggest Pogba could be available, he’s thought to be sidelined with a knock.
Pogba was injured before last weekend’s matcha against Liverpool. Scott McTominay injured his team mate in training on Friday.
Predicted XIs: Man United vs Sevilla
The Times on Tuesday morning have had a stab at predicting the line-ups.
Starting with Man United’s attack, Romelu Lukaku is predicted to be supported by Alexis Sanchez playing in the number 10 role.
Marcus Rashford, fresh from his double vs Liverpool, could start on the left. Jesse Lingard, rather than Anthony Martial or Juan Mata, is set to start on the right.
At the back, Eric Bailly should partner Chris Smalling at the heart of the United defence.
When it comes to Sevilla, Luis Muriel is tipped to start in attack ahead of Wissam Ben Yedder.
Sevilla 0 – Valencia 2
While Man United beat Liverpool last weekend, Sevilla lost 2-0 at home to Valencia.
The scoreline was slightly misleading, as Sevilla played pretty well against Los Che without taking their chances.